Connexin Cell Communication Channels Roles in the Immune System and Immunopathology

Connexin Cell Communication Channels Roles in the Immune System and Immunopathology

Publisher

CRC Press

Language

‎English

Edition

1st

ISBN-10

1439862575

ISBN-13

978-1439862575, 9781439862575

$131.83

5/5
Description

Connexin Cell Communication Channels Roles in the Immune System and Immunopathology 

In the realm of immunological processes, crucial functional roles are attributed to plasma membrane-associated channels known as gap junctions, and their constituting protein elements referred to as connexins.

This intricate interplay has profound implications spanning across various domains such as heart functionality, cellular growth and specialization, and early developmental stages.

The publication titled “Connexin Cell Communication Channels Roles in the Immune System and Immunopathology” serves as a comprehensive consolidation of four decades’ worth of pivotal research endeavors conducted within this sphere.

The initial segment of Connexin Cell Communication Channels Roles in the Immune System and Immunopathology offers a retrospective glance at the discovery of these distinctive membrane channels within cells and tissues of the immune system.

It elucidates their inherent molecular and biological attributes, meticulously examining their contributions towards the evolution, arrangement, operation, and regulation of leukocytes, while also delving into their intricate interplay with other tissue types.

Proceeding forward, the subsequent section delves into scenarios of immunologically associated diseases, where the profound involvement of gap junctions and connexins has been substantiated.

Contributors expound upon the integral role of gap junctional communication in the establishment and perpetuation of immunological properties, encompassing the generation of antibodies, cytokines, and the immune surveillance undertaken by lymphocytes in both physiological and pathological contexts.

Connexin Cell Communication Channels Roles in the Immune System and Immunopathology (Free Download)

Connexin Cell Communication Channels Roles in the Immune System and Immunopathology (Free Download)

This segment of the book meticulously explores the array of technical methodologies employed, specifically tailored to address pivotal biological inquiries, taking into account the mobile nature of leukocytes.

Additionally, it furnishes insights into the latest comprehension of the contributions rendered by gap junctions and connexins in the realms of antigen recognition, cross-presentation, lymphocyte activation, and the assembly and operation of the immunological synapse.

In its final stride, the book assumes a concentrated perspective on the recent advancements in translating the accrued knowledge into distinct therapeutic modalities.

The themes encompassed in this section are diverse, ranging from strategies aimed at mitigating scarring and cardiac arrhythmia to combating inflammation within the central nervous system and augmenting the process of epithelial tissue restoration.

Offering an all-encompassing vista of accomplishments within this promising domain, this publication holds the potential to edify and apprise specialists, clinical practitioners, and individuals engaged in the study of commercial applications, with regard to the multifaceted dimensions presented by “Connexin Cell Communication Channels Roles in the Immune System and Immunopathology.

1.2.Key Features

The most prominent key features of “Connexin Cell Communication Channels Roles in the Immune System and Immunopathology” are:

  1. Comprehensive Exploration: Connexin Cell Communication Channels Roles in the Immune System and Immunopathology provides an in-depth and comprehensive exploration of the role of connexin-based gap junctions in the immune system, offering a thorough understanding of their molecular and biological characteristics.
  2. Historical Overview: The publication begins with a historical overview, tracing the discovery and evolution of membrane channels within immune system cells and tissues, establishing a foundation for the subsequent discussions.
  3. Disease Relevance: A significant highlight lies in the Connexin Cell Communication Channels Roles in the Immune System and Immunopathology examination of how gap junctions and connexins play pivotal roles in immunologically related disease scenarios. This aspect underlines their fundamental involvement in immune responses and immunopathological conditions.
  4. Interdisciplinary Approach: The book seamlessly combines insights from basic science with potential clinical applications, bridging the gap between theoretical understanding and practical implications.
  5. In-Depth Technical Insight: It offers a comprehensive overview of the technical methodologies employed in studying these communication channels, particularly tailored to address the unique challenges posed by mobile leukocytes.
  6. Immunological Processes: The book thoroughly elucidates how gap junctional communication contributes to essential immunological processes, including antibody and cytokine production, lymphocyte immune surveillance, antigen recognition, cross-presentation, and the formation of the immunological synapse.
  7. Clinical Implications: One of the most valuable features is the book’s focus on translating research findings into potential clinical treatments. This section discusses applications such as reducing scarring, managing cardiac arrhythmia, addressing inflammation in the central nervous system, and promoting epithelial tissue repair.
  8. Expert Contributors: The book benefits from contributions by experts in the field, ensuring a well-rounded and authoritative compilation of knowledge and insights.
  9. Informative for Diverse Audiences: With its balanced blend of scientific detail and clinical relevance, the book is a valuable resource for specialists, clinical practitioners, researchers, and those interested in commercial applications in the realm of immunology.
  10. Four Decades of Research: One of the book’s remarkable aspects is its synthesis of four decades of significant research, offering a comprehensive and up-to-date perspective on the field’s advancements.
  11. Synthesis of Knowledge: It serves as a synthesis point for a wide range of research efforts and findings, bringing together fragmented pieces of knowledge into a cohesive narrative about the roles of connexin cell communication channels in the immune system and immunopathology.

These key features collectively make “Connexin Cell Communication Channels Roles in the Immune System and Immunopathology” an invaluable resource for understanding the intricate interplay between connexins, gap junctions, and the immune system, while also highlighting their potential implications in clinical setting.

Connexin Cell Communication Channels Roles in the Immune System and Immunopathology (Free Download)

Connexin Cell Communication Channels Roles in the Immune System and Immunopathology

1.3. About Writer

Ernesto Oviedo-Orta is a distinguished editor known for his significant contributions to the field of immunology and cell communication.

With expertise in connexin-based gap junctions, Oviedo-Orta has co-edited the influential book “Connexin Cell Communication Channels Roles in the Immune System and Immunopathology.”

His research has significantly advanced our understanding of how these communication channels impact immunological processes, bridging the gap between basic science and clinical applications.

Brenda R. Kwak is a notable editor recognized for her substantial involvement in immunological research.

Her co-editorship of “Connexin Cell Communication Channels” underscores her dedication to advancing knowledge about the roles of gap junctions and connexins in immunopathology.

Kwak’s expertise contributes to the book’s comprehensive overview of the subject, providing insights that inform specialists, clinical practitioners, and researchers alike.

William Howard Evans, a distinguished editor in the field of immunology, has made significant contributions to the study of connexin-based gap junctions.

His co-editorship of “Connexin Cell Communication Channels” highlights his commitment to synthesizing decades of research into a cohesive resource.

Evans’ expertise enriches the book’s exploration of gap junctions’ roles in immune function, disease, and potential therapeutic application.

Connexin Cell Communication Channels Roles in the Immune System and Immunopathology (Free Download)

Connexin Cell Communication Channels Roles in the Immune System and Immunopathology (Free Download)

Summary

Connexin Cell Communication Channels Roles in the Immune System and Immunopathology” presents a comprehensive and authoritative exploration of the pivotal roles played by gap junctions and connexins in the immune system and related disease scenarios.

Editors Ernesto Oviedo-Orta, Brenda R. Kwak, and William Howard Evans, along with expert contributors, synthesize four decades of research to provide an in-depth understanding of these membrane channels’ molecular characteristics, their involvement in immune evolution, organization, and regulation, and their contributions to immunological properties such as cytokine production, lymphocyte surveillance, and antigen recognition.

The book further delves into their relevance in immunopathological conditions and their potential therapeutic applications, making it an essential resource for specialists, clinical practitioners, and researchers seeking to bridge the gap between fundamental immunology and clinical practice.”

 

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