Pharmacogenomics An Introduction and Clinical Perspective (Original PDF from Publisher)

“Pharmacogenomics An Introduction and Clinical Perspective” presents a comprehensive and accessible overview of the dynamic field of pharmacogenomics, with a diverse global author team comprised of PharmDs, MDs, PhDs, and social scientists.

This introductory resource offers thorough coverage of essential topics, spanning from individual molecular mechanisms to systemic diseases, and explores the latest advancements that continuously reshape this discipline.

Divided into two cohesive sections, the book delves into fundamental aspects such as ethics, regulation, science, and drug metabolism, accompanied by a concise molecular genetics and testing primer.

The second section highlights the practical application of pharmacogenomics across specialties like cardiovascular medicine, neurology, and immunology.

With an emphasis on gene-drug interactions, regulatory considerations, and broader ethical and social issues, the book provides step-by-step guidance on patient counseling and public access to pharmacogenomic testing.

Through its focused chapters, illustrative tables and figures, case studies, and learning objectives, this resource equips readers with a robust understanding of the field’s clinical implications and importance in modern healthcare.

Pharmacogenomics An Introduction and Clinical Perspective

1.2.Key Features

The key features of the book “Pharmacogenomics An Introduction and Clinical Perspective” include:

1. Diverse Author Team: The book is authored by a global team of experts, including professionals with PharmD, MD, PhD, and social science backgrounds, ensuring a comprehensive and multidisciplinary perspective on pharmacogenomics.
2. Comprehensive Coverage: The book offers a thorough exploration of pharmacogenomics, covering a wide range of topics from basic concepts to systemic diseases, providing a complete understanding of the field.
3. Practical Application: It not only delves into theoretical concepts but also highlights the practical application of pharmacogenomics in various medical specialties, such as cardiovascular medicine, neurology, and immunology.
4. Ethical and Regulatory Considerations: The book addresses the ethical, legal, and social considerations associated with pharmacogenomics, providing insights into the broader implications of this field in healthcare.
5. Gene-Drug Interactions: With an emphasis on gene-drug interactions, the book explains how genetic variations can impact drug responses and patient outcomes.
6. Learning Tools: The book includes concise learning objectives at the beginning of each chapter, case studies that illustrate the clinical relevance of pharmacogenomics, numerous tables and figures for easy comprehension, and references to further enhance learning.
7. Patient Counseling Guidance: It offers step-by-step guidance on public access to pharmacogenomic testing and patient counseling, ensuring practical insights for healthcare professionals.
8. Updated Content: The book includes up-to-date coverage of both genetic and non-genetic influences on pharmacogenomics, reflecting the latest advancements in the field.
9. Focus on Drug Metabolism: In-depth chapters on drug metabolism and transporters provide a solid foundation for understanding how pharmacogenomics influences drug response.
10. Clinical Perspective: The book bridges the gap between theory and practice, offering a clinical perspective that highlights the real-world implications of pharmacogenomics in patient care.

Pharmacogenomics An Introduction and Clinical Perspective (Original PDF from Publisher)

1.3. About Writer

Joseph S. Bertino, MD, is a distinguished medical researcher and practitioner known for his groundbreaking contributions to oncology and pharmacology.

He has held prominent positions at several esteemed institutions, including Yale University, where he served as the Director of the Cancer Center, and Rutgers University, where he became a Professor of Medicine.

Dr. Bertino’s pioneering work in cancer chemotherapy and personalized medicine has earned him numerous accolades, including the prestigious Lasker-DeBakey Clinical Medical Research Award.

Angela Kashuba, PharmD, is a renowned expert in clinical pharmacology and pharmacokinetics. She has made significant contributions to HIV research, focusing on optimizing drug therapies for patients with HIV/AIDS.

Dr. Kashuba has held leadership roles in various academic institutions, including the University of North Carolina at Chapel Hill, where she serves as the Dean of the Eshelman School of Pharmacy.

Her research has garnered recognition from organizations like the American Association of Pharmaceutical Scientists.

Joseph D. Ma, MD, PhD, is an accomplished physician-scientist with expertise in clinical pharmacology and oncology. He has been involved in groundbreaking research on drug metabolism and pharmacogenomics, contributing to the development of personalized medicine approaches in cancer treatment.

Dr. Ma has held faculty positions at institutions like Washington University School of Medicine and the Mayo Clinic, showcasing his dedication to advancing medical knowledge and patient care.

Uwe Fuhr, MD, PhD, is a respected researcher in clinical pharmacology and pharmacogenetics.

His work has shed light on the genetic factors influencing drug metabolism and responses, contributing to the field’s understanding of individualized drug therapy.

Dr. Fuhr’s academic roles have included positions at renowned institutions such as the University of Cologne in Germany, where he has shared his expertise with the scientific community.

Lindsay DeVane, PharmD, is a distinguished researcher and educator in clinical psychopharmacology and pharmacokinetics. His contributions to the field of psychiatry include elucidating the pharmacological mechanisms of psychotropic medications. Dr. DeVane has held faculty positions at institutions such as the Medical University of South Carolina and the University of Florida, showcasing his commitment to advancing psychiatric pharmacotherapy.

Collectively, these authors bring a wealth of expertise to the book “Pharmacogenomics An Introduction and Clinical Perspective,” enriching it with their extensive knowledge and achievements in the fields of oncology, clinical pharmacology, pharmacokinetics, and personalized medicine.

Pharmacogenomics An Introduction and Clinical Perspective (Original PDF from Publisher)

Summary

“Pharmacogenomics An Introduction and Clinical Perspective” is a comprehensive and accessible resource that provides a thorough exploration of the dynamic field of pharmacogenomics.

Authored by a diverse team of experts including Joseph S. Bertino, Angela Kashuba, Joseph D. Ma, Uwe Fuhr, and C. Lindsay DeVane, the book offers a well-structured overview of key concepts in pharmacogenomics, ranging from genetic variation and drug metabolism to ethical considerations and regulatory aspects.

The text highlights the critical role of health care professionals and addresses privacy issues, while also delving into the practical application of pharmacogenomics across various medical specialties.

With practical guidance on patient counseling, in-depth coverage of gene-drug interactions, and clinical case studies that demonstrate the clinical relevance of pharmacogenomics, this book is an indispensable guide for both students and practitioners seeking a comprehensive understanding of pharmacogenomics and its implications in personalized medicine and patient care.

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